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Mavacamten boosts quality of life in patients with hypertrophic cardiomyopathy

Publish date: June 4, 2021 Of patients with symptomatic, obstructive hypertrophic cardiomyopathy treated with the investigational oral agent mavacamten, more than twice as many, compared with placebo, had a very large improvement from baseline in their summary quality of life score after 30 weeks of treatment in a pivotal trial with 194 patients evaluable for this […]

PHOTO GALLERY: How COVID-19 Appears on Medical Imaging

MAY 27, 2021 | DAVE FORNELL, EDITOR The photo gallery below shows the variety of radiological presentations of COVID-19 (SARS-CoV-2) in medical imaging, including computed tomography (CT), radiograph X-rays, ultrasound, echocardiograms and magnetic resonance imaging (MRI). The radiology images show examples of typical COVID pneumonia in the lungs and the numerous complications the virus causes in the body in multiple […]

Left Atrial Appendage Occlusion during Cardiac Surgery to Prevent Stroke

May 15, 2021 DOI: 10.1056/NEJMoa2101897 Surgical occlusion of the left atrial appendage has been hypothesized to prevent ischemic stroke in patients with atrial fibrillation, but this has not been proved. The procedure can be performed during cardiac surgery undertaken for other reasons. We conducted a multicenter, randomized trial involving participants with atrial fibrillation and a […]

Multivessel PCI Guided by FFR or Angiography for Myocardial Infarction

May 16, 2021 DOI: 10.1056/NEJMoa2104650 In patients with ST-elevation myocardial infarction (STEMI) who have multivessel disease, percutaneous coronary intervention (PCI) for nonculprit lesions (complete revascularization) is superior to treatment of the culprit lesion alone. However, whether complete revascularization that is guided by fractional flow reserve (FFR) is superior to an angiography-guided procedure is unclear. In […]

Valve Academic Research Consortium 3: updated endpoint definitions

European Heart Journal, Volume 42, Issue 19, 14 May 2021, Pages 1825 1857, https://doi.org/10.1093/eurheartj/ehaa799 Published: 19 April 2021 The Valve Academic Research Consortium (VARC), founded in 2010, was intended to (i) identify appropriate clinical endpoints and (ii) standardize definitions of these endpoints for transcatheter and surgical aortic valve clinical trials. Rapid evolution of the field, […]

Left ventricular segmental strain and the prediction of cancer therapy-related cardiac dysfunction

European Heart Journal – Cardiovascular Imaging, Volume 22, Issue 4, April 2021, Pages 418-426, https://doi.org/10.1093/ehjci/jeaa288 Published: 18 November 2020 In a cohort of 237 women with breast cancer receiving doxorubicin with or without trastuzumab, 1151 echocardiograms were prospectively acquired over a median (Q1–Q3) of 7 (2–24) months. LV ejection fraction (LVEF) and 36 segmental strain […]

Posterior Left Atrial Adipose Tissue Attenuation Assessed by Computed Tomography and Recurrence of Atrial Fibrillation After Catheter Ablation

Originally published15 Mar 2021 https://doi.org/10.1161/CIRCEP.120.009135 Circulation: Arrhythmia and Electrophysiology. 2021;14   Atrial fibrillation (AF) recurrence following catheter ablation remains high. Recent studies have shown a relation between epicardial adipose tissue and AF. epicardial adipose tissue secretes several proinflammatory and anti-inflammatory adipokines that directly interact with the adjacent myocardium. The aim of the current study was […]

Myocardial remodelling after withdrawing therapy for heart failure in patients with recovered dilated cardiomyopathy: insights from TRED‐HF

First published: 22 November 2020  https://doi.org/10.1002/ejhf.2063 To characterize adverse ventricular remodelling after withdrawing therapy in recovered dilated cardiomyopathy (DCM). TRED‐HF was a randomized controlled trial with a follow‐on single‐arm cross‐over phase that examined the safety and feasibility of therapy withdrawal in patients with recovered DCM over 6 months. The primary endpoint was relapse of heart failure […]

Cardiology training using technology

European Heart Journal, Volume 42, Issue 15, 14 April 2021, Pages 1453-1455  https://doi.org/10.1093/eurheartj/ehaa1030   Published: 28 December 2020 The coronavirus disease-2019 (COVID-19) pandemic has had an unparalleled impact on cardiology training worldwide. In the next few sections, we highlight several foundational considerations for building a successful technology-enabled model in the new normal for cardiology training. […]

Cryoblation as first-line treatment of new-onset atrial fibrillation?

European Heart Journal, Volume 42, Issue 16, 21 April 2021, Pages 1543-1544, https://doi.org/10.1093/eurheartj/ehab161 Published: 24 March 2021   The European Society of Cardiology Guidelines for the diagnosis and management of AF3 recommend (Class IA) rhythm control therapy for symptom and quality of life improvement in symptomatic patients with AF. However, for rhythm control, catheter ablation is […]

Immersive 3D virtual reality imaging in planning minimally invasive and complex adult cardiac surgery

European Heart Journal – Digital Health, Volume 1, Issue 1, November 2020, Pages 62-70, https://doi.org/10.1093/ehjdh/ztaa011 Published: 23 November 2020 Increased complexity in cardiac surgery over the last decades necessitates more precise preoperative planning to minimize operating time, to limit the risk of complications during surgery and to aim for the best possible patient outcome. Novel, […]

New Class of Radially Adjustable Stentrievers for Acute Ischemic Stroke

Originally published19 Mar 2021 https://doi.org/10.1161/STROKEAHA.121.034436 Stroke. 2021;52:1534–1544   The Tigertriever is a novel, radially adjustable, fully visible, stentriever that permits the operator to align radial expansion with target vessel diameters. This multicenter trial compared the Tigertriever’s effectiveness and safety compared with established stent retrievers. Single arm, prospective, multicenter trial comparing the Tigertriever to efficacy and […]

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Προτεινόμενα πρόσφατα επιστημονικά άρθρα

European Heart Journal, ehab153, https://doi.org/10.1093/eurheartj/ehab153 Published: 22 March 2021

European Heart Journal, ehab153, https://doi.org/10.1093/eurheartj/ehab153 Published: 22 March 2021

European Heart Journal, ehab242, https://doi.org/10.1093/eurheartj/ehab242 Published: 23 May 2021

European Heart Journal, Volume 42, Issue 19, 14 May 2021, Pages 1879–1882, https://doi.org/10.1093/eurheartj/ehab145 Published: 13 March 2021

May 15, 2021 DOI: 10.1056/NEJMoa2102137

European Heart Journal, ehab241, https://doi.org/10.1093/eurheartj/ehab241 Published: 13 May 2021

European Heart Journal, ehab221, https://doi.org/10.1093/eurheartj/ehab221 Published: 07 May 2021

European Heart Journal, ehab253, https://doi.org/10.1093/eurheartj/ehab253 Published: 05 May 2021